Open Access Open Access  Restricted Access Subscription or Fee Access

Experimental Background, Designs and Bioengineering Applications of Microfluidic Immunosensor Devices

Subhadeep Mukhopadhyay

Abstract


In this short review, the microfluidic Immunosensor devices are briefly reviewed. In the last few years, the experimental techniques have been developed to immobilize the antibodies and other relevant molecules. Also, surface modification techniques have been developed to resist the non-specific adsorption. Fluorescence and electrochemistry are used as detection methods. In future, the microfluidic Immunosensor devices will be used for better sensitive detection, miniaturization, increased integration, multianalyte analysis and many more. This educational short review is authored as the study material for proposed elective-course on Microfluidics (M.Tech, Theory) in the Department of Mechanical Engineering of the National Institute of Technology Arunachal Pradesh, India.

Full Text:

PDF

References


A. Bange, H. B. Halsall, W. R. Heineman. Microfluidic immunosensor systems, Biosens Bioelectron. 2005; 20: 2488–503p.

S. Mukhopadhyay, J. P. Banerjee, A. Mathur, M. Tweedie, J. A. McLaughlin, S. S. Roy. Experimental studies of surface-driven capillary flow in PMMA microfluidic devices prepared by direct bonding technique and passive separation of microparticles in microfluidic laboratory-on-a-chip systems, Surf Rev Lett. 2015; 22: 1550050p.

S. Mukhopadhyay, J. P. Banerjee, S. S. Roy, S. K. Metya, M. Tweedie, J. A. McLaughlin. Effects of surface properties on fluid engineering generated by the surface-driven capillary flow of water in microfluidic lab-on-a-chip systems for bioengineering applications, Surf Rev Lett. 2017; 24: 1750041p.

S. Mukhopadhyay. Optimisation of the experimental methods for the fabrication of polymer microstructures and polymer microfluidic devices for bioengineering applications, J Polym Compos. 2016; 4: 8–26p.

S. Mukhopadhyay. Experimental investigations on the interactions between liquids and structures to passively control the surface-driven capillary flow in microfluidic lab-on-a-chip systems to separate the microparticles for bioengineering applications, Surf Rev Lett. 2017; 24: 1750075p.

S. Mukhopadhyay. Experimental investigations on the surface-driven capillary flow of aqueous microparticle suspensions in the microfluidic laboratory-on-a-chip systems, Surf Rev Lett. 2017; 24: 1750107p.

S. Mukhopadhyay. Experimental investigations on the effects of surface modifications to control the surface-driven capillary flow of aqueous working liquids in the PMMA microfluidic devices, Adv Sci Eng Med. 2017; 9: 959–70p.

S. Mukhopadhyay. Report on the separation efficiency with separation time in the microfluidic lab-on-a-chip systems fabricated by polymers in this 21st century of 3rd millennium, J Exp Appl Mech. 2016; 7: 20–37p.

C. W. Tsao, D. L. DeVoe. Bonding of thermoplastic polymer microfluidics, Microfluid Nanofluid. 2009; 6: 1–16p.

H. Becker, L. E. Locascio. Polymer microfluidic devices, Talanta. 2002; 56: 267–87p.




DOI: https://doi.org/10.37628/ijtet.v4i1.766

Refbacks

  • There are currently no refbacks.